Timothy C Nichols Selected Research

Factor IX (Coagulation Factor IX)

1/2022	Dexamethasone Transiently Enhances Transgene Expression in the Liver When Administered at Late-Phase Post Long-Term Adeno-Associated Virus Transduction.
1/2021	Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants.
1/2020	Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa.
1/2017	Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models.
3/2015	Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs.
1/2014	Portal vein delivery of viral vectors for gene therapy for hemophilia.
1/2012	Animal models of hemophilia.
8/2011	Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide.
5/2011	Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk.
11/2010	Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.

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Timothy C Nichols Research Topics

Disease

25	Hemophilia B (Haemophilia B) 01/2022 - 04/2002
25	Hemorrhage 01/2019 - 05/2003
23	Hemophilia A (Haemophilia) 12/2019 - 10/2002
6	Atherosclerosis 11/2019 - 07/2005
6	von Willebrand Diseases (von Willebrand's Disease) 02/2013 - 07/2003
3	Inflammation (Inflammations) 11/2019 - 03/2004
3	Myocardial Infarction 11/2013 - 03/2003
3	Vascular System Injuries 01/2013 - 11/2003
3	Wounds and Injuries (Trauma) 10/2010 - 09/2005
2	Foreign Bodies (Foreign Body) 01/2021 - 01/2018
2	Liver Diseases (Liver Disease) 12/2019 - 06/2010
2	Coronary Artery Disease (Coronary Atherosclerosis) 11/2019 - 01/2015
2	Neoplasms (Cancer) 01/2019 - 01/2013
2	Insulin Resistance 01/2015 - 01/2006
2	Thrombosis (Thrombus) 11/2013 - 01/2010
2	Erythema 02/2013 - 10/2011
2	Flushing 02/2013 - 10/2011
2	Reperfusion Injury 03/2004 - 03/2003
1	Lung Neoplasms (Lung Cancer) 01/2019
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019
1	Retinoblastoma (Glioblastoma, Retinal) 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Hemarthrosis 01/2016
1	Pathologic Constriction (Stenosis) 03/2015
1	Rupture 03/2015
1	Weight Gain 01/2015
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2014
1	ST Elevation Myocardial Infarction 11/2013
1	Lymphoma (Lymphomas) 01/2013
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2013

Drug/Important Bio-Agent (IBA)

21	Factor IX (Coagulation Factor IX)FDA LinkGeneric 01/2022 - 04/2002
15	Factor VIII (Coagulation Factor VIII)IBA 01/2017 - 10/2002
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2005
7	AntibodiesIBA 01/2017 - 12/2003
6	AntigensIBA 01/2017 - 05/2003
4	CollagenIBA 01/2019 - 11/2003
4	Hemostatics (Antihemorrhagics)IBA 01/2016 - 10/2003
4	von Willebrand FactorIBA 01/2010 - 07/2003
3	Neutralizing AntibodiesIBA 12/2019 - 12/2010
3	LipidsIBA 11/2019 - 03/2015
3	Pharmaceutical PreparationsIBA 01/2017 - 01/2011
3	7,7'- dimethoxy- (4,4'- bi- 1,3- benzodioxole)- 5,5'- dicarboxylic acid dimethyl ester (BDD)IBA 10/2016 - 11/2009
3	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 02/2013 - 07/2003
3	oprelvekin (Neumega)FDA Link 02/2013 - 07/2003
3	Interleukin-11 (Interleukin 11)IBA 02/2013 - 07/2003
3	Factor VIIa (Activated Factor VII)IBA 12/2011 - 04/2009
3	recombinant FVIIa (rFVIIa)FDA Link 08/2011 - 05/2008
3	NF-kappa B (NF-kB)IBA 03/2004 - 03/2003
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 01/2018
2	Blood Coagulation Factors (Coagulation Factor)IBA 12/2019 - 12/2011
2	CalciumIBA 01/2019 - 12/2017
2	Biological ProductsIBA 10/2016 - 02/2013
2	Factor VII (Proconvertin)IBA 02/2016 - 12/2011
2	oxidized low density lipoproteinIBA 01/2015 - 11/2013
2	polysaccharide intercellular adhesinIBA 08/2011 - 09/2005
2	Transcription Factors (Transcription Factor)IBA 03/2004 - 03/2003
2	Glycoproteins (Glycoprotein)IBA 11/2003 - 07/2003
2	A-factor (Streptomyces)IBA 10/2002 - 04/2002
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2022
1	GlucocorticoidsIBA 01/2022
1	lipid phosphate phosphataseIBA 11/2019
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2019
1	Lysophosphatidic Acid ReceptorsIBA 11/2019
1	Phospholipids (Phosphatides)FDA LinkGeneric 11/2019
1	Taxoids (Taxanes)IBA 01/2019
1	palbociclibIBA 01/2019
1	Retinoblastoma ProteinIBA 01/2019
1	taxaneIBA 01/2019
1	Streptozocin (Streptozotocin)FDA Link 01/2018
1	Capsules (Microcapsules)IBA 01/2018
1	Thrombin FDA Link 01/2017
1	Immunoglobulin E (IgE)IBA 01/2017
1	Immunoglobulin G (IgG)IBA 01/2017
1	Tyrosine (L-Tyrosine)FDA Link 01/2017
1	Recombinant ProteinsIBA 10/2016
1	FurinIBA 10/2016
1	DNA Restriction Enzymes (Restriction Endonuclease)IBA 01/2016
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2016
1	Nonsense Codon (Nonsense Mutation)IBA 01/2016
1	B-domain-deleted factor VIIIIBA 01/2016
1	Lipid NanoparticlesIBA 01/2016
1	Amino Acids FDA Link 01/2016
1	Phenobarbital (Luminal)FDA Link 03/2015
1	Biomarkers (Surrogate Marker)IBA 03/2015
1	Glycated ProteinsIBA 01/2015
1	Insulin (Novolin)FDA Link 01/2015
1	HDL CholesterolIBA 01/2015
1	FructosamineIBA 01/2015
1	LDL Receptors (LDL Receptor)IBA 01/2014
1	LDL Lipoproteins (beta Lipoproteins)IBA 11/2013
1	Indicators and Reagents (Reagents)IBA 01/2013
1	Docetaxel (Taxotere)FDA Link 01/2013
1	LuciferasesIBA 01/2013
1	alovudineIBA 01/2013
1	Tissue ExtractsIBA 01/2013

Therapy/Procedure

12	Therapeutics 01/2019 - 12/2003
2	Intravenous Administration 01/2020 - 12/2003
2	Drug Therapy (Chemotherapy) 01/2019 - 01/2013
2	Punctures 12/2011 - 07/2009
1	Injections 01/2020